項(xiàng)目                                  USP級
                                    （USP )
identity                              pass
specific rotation                    +107°- +121°  （10 %, H2O）
ph test                              3.5 to 5.5 (4% solution)
loss on drying                       ≥ 18.0%
residue on ignition                  ≥ 1.0%
limit of methanol                    ≥ 1.0%
gentamicin c1                        25% to 50%
gentamicin c1a                       10% to 35%
gentamicin c2a+c2                    25% to 55%
residual solvents                    meets the requirements
assay                                ≥ 590 ug/mg (dry basis)


potency: ≥590 μg Gentamicin per mg：

含量Assay (Gentamycin base):          ≥590 μg/mg  
比旋光度α20°C /D                     +107°- +121°  （10 %, H2O）
pH (4 %; H2O)                         3.5 - 5.5  
水分Water                             ≤15 % (K.F.)
硫酸根Sulfate:                        32 - 35 %  

慶大霉素靠結(jié)合到30S核糖體亞單位上引起密碼讀錯，阻斷肽酰-tRNA（peptidyl-tRNA）從受體位點(diǎn)到供體點(diǎn)點(diǎn)的轉(zhuǎn)移。慶大霉素對假單胞桿菌的殺菌效果靠結(jié)合到細(xì)胞膜的外膜部分，置換本來存在的陽離子，使膜不穩(wěn)定，在細(xì)胞表面形成空洞。
抗菌譜: 革蘭氏陰性細(xì)菌，葡萄狀球菌和其它的革蘭氏陽性細(xì)菌。